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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK6
All Species:
34.55
Human Site:
S155
Identified Species:
54.29
UniProt:
Q00534
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00534
NP_001138778.1
326
36938
S155
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116412
303
33725
S150
P
E
N
I
L
V
T
S
G
G
T
V
K
L
A
Dog
Lupus familis
XP_852360
326
36788
S155
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
Cat
Felis silvestris
Mouse
Mus musculus
Q64261
326
37010
S155
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
Rat
Rattus norvegicus
P35426
303
33780
S150
P
E
N
I
L
V
T
S
N
G
T
V
K
L
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511310
202
22667
T53
Y
S
F
Q
M
A
L
T
S
V
V
V
T
L
W
Chicken
Gallus gallus
P13863
303
34670
G140
N
L
L
I
D
D
K
G
V
I
K
L
A
D
F
Frog
Xenopus laevis
Q91727
319
35666
S150
P
E
N
I
L
V
T
S
G
G
Q
V
K
L
A
Zebra Danio
Brachydanio rerio
NP_001137525
302
33962
S152
P
Q
N
I
L
V
T
S
G
G
Q
I
K
L
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477196
317
36383
S167
P
Q
N
L
L
V
S
S
Q
G
H
L
K
I
A
Honey Bee
Apis mellifera
XP_391955
457
50351
R307
P
Q
N
L
L
V
T
R
E
G
R
I
K
I
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999689
373
42086
S156
P
Q
N
I
L
V
A
S
D
K
K
L
K
L
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
N140
L
L
I
D
R
R
T
N
A
L
K
L
A
D
F
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
N140
L
L
I
D
R
R
T
N
S
L
K
L
A
D
F
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
K146
P
Q
N
L
L
I
N
K
D
G
N
L
K
L
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
65.6
96.6
N.A.
96.3
65
N.A.
56.1
43.5
65.3
76
N.A.
42.6
37.6
N.A.
50.6
Protein Similarity:
100
N.A.
76
97.5
N.A.
98.1
76
N.A.
58.5
61.9
77.9
83.1
N.A.
63.7
50.5
N.A.
63
P-Site Identity:
100
N.A.
73.3
100
N.A.
100
73.3
N.A.
13.3
6.6
80
93.3
N.A.
60
66.6
N.A.
60
P-Site Similarity:
100
N.A.
86.6
100
N.A.
100
93.3
N.A.
33.3
20
93.3
93.3
N.A.
86.6
86.6
N.A.
73.3
Percent
Protein Identity:
N.A.
44.4
N.A.
44.7
40.1
N.A.
Protein Similarity:
N.A.
62.2
N.A.
62.2
59.8
N.A.
P-Site Identity:
N.A.
6.6
N.A.
13.3
46.6
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
33.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
7
0
7
0
0
0
20
0
60
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
14
7
7
0
0
14
0
0
0
0
20
0
% D
% Glu:
0
20
0
0
0
0
0
0
7
0
0
0
0
0
0
% E
% Phe:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
20
% F
% Gly:
0
0
0
0
0
0
0
7
20
67
0
0
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
0
14
60
0
7
0
0
0
7
0
34
0
14
0
% I
% Lys:
0
0
0
0
0
0
7
7
0
7
27
0
74
0
0
% K
% Leu:
14
20
7
20
74
0
7
0
0
14
0
40
0
67
0
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
74
0
0
0
7
14
7
0
7
0
0
0
0
% N
% Pro:
74
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
54
0
7
0
0
0
0
7
0
34
0
0
0
0
% Q
% Arg:
0
0
0
0
14
14
0
7
0
0
7
0
0
0
0
% R
% Ser:
0
7
0
0
0
0
7
60
34
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
67
7
0
0
14
0
7
0
7
% T
% Val:
0
0
0
0
0
67
0
0
7
7
7
27
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _